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Add to My Companies | Give a Referral for this Company | Print this ProfilePartnership and licensing opportunities from Repertoire Immune Medicines.
Each T cell expresses unique T cell receptors (TCRs) on its surface which recognize a specific peptide fragment of an antigen, called epitopes, that are presented on the antigen presenting cell by human leukocyte antigen (HLA) molecules. HLA molecules are among the most complex molecules in our bodies and are highly diverse across populations. Class I HLA molecules present peptides from inside a cell and activate CD8+ T cells, allowing them to kill cancer cells, for example. Class II HLA molecules present antigens taken up from the outside of the cell, process them, and present them to CD4+ T cells. This activation of CD4+ T cells drives a number of cascading immune responses, including production of inflammatory cytokines and activation of B cells and macrophages.
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