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The core of Agios remains our research engine, from a robust discovery toolkit to a focus on the deep biological interrogation of prospective targets and mechanisms of action. Translational thinking is embedded across programs early in research, to ensure a rapid and successful transition to the clinic. Once in the clinic, we embrace trial designs that allow for rapid clinical proof of concept, guiding the subsequent development path. We are committed to leveraging our established and growing commercial presence to both deliver medicines to patients worldwide and maximize value for Agios and its partners. Across all functions and stages of development, Agios embraces its “Other Side of Possible” (OSOP) culture to accomplish the extraordinary while prioritizing the patients whom we seek to serve.