Sirona Dx

Sirona Dx is a technical CRO, providing advanced, high complexity, single cell, multi omics services to accelerate the pace of immunotherapy and targeted therapy development. In contrast to most CROs, we embrace leading edge technologies at an earlier stage, often assisting life science companies with product development. Bridging the silos between tools developers and biopharma means our clients access enabling technologies and expertise sooner and within a CLIA accredited, GCLP laboratory that supports pharma regulatory requirements. Our team can assist with platform selection and with the design, optimization and validation of complex multi-analyte assays. Harness breakthrough technologies to profile and integrate biology with single-cell resolution including tissue spatial context to reveal the next generation of precision biomarker signatures to accelerate therapies towards regulatory approval. Recognized as the original pioneers of spatial biology we launched the first spatial-omics CRO service in 2018 utilizing IMC technology developed by Fluidigm. Today our technology agnostic, spatial biology suite includes all of the leading multiplexed imaging platforms. Our team can develop panels of up to 40 markers to reveal the complex interplay between the immune system and the tumor/tissue microenvironment. We leverage CyTOF technology from Fluidigm to perform ultradeep immune profiling of whole blood and PBMCs with highly multiplexed assays of 40+ markers. High performance RNA extraction methodologies coupled with a comprehensive menu of high parameter IO expression profiling assays supports exploration of complex tumor immunobiology from challenging sample types.